VNN1

Across TCGA pan-cancer cohorts, VNN1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of VNN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where VNN1 RNA is repressed in tumor relative to normal tissue. In most cancer types VNN1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KICH, LIHC, and COAD are the cancer types where VNN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VNN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−3.120	<.001	8	view →
LIHC	Male	II,III,IV	−2.684	<.001	7	view →
COAD	Male	II,III,IV	+1.428	.001	5	view →
KIRP	Female	II,III,IV	−2.674	.015	4	view →
CHOL	All	All	−2.435	.001	4	view →
BRCA	All	II,III,IV	−0.356	.002	4	view →
ESCA	All	II,III,IV	+4.220	.008	3	view →
STAD	Female	III,IV	+2.300	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

VNN1–KICH

Open the KICH breakdown →