VNN1

Across TCGA patient cohorts, VNN1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VNN1-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and MEK1. Each is linked with VNN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VNN1-to-partner and partner-to-VNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by VNN1-low versus VNN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN1→partner) and Y-score (partner→VNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.320	+1.247	.017	.045	3	2
UCEC	JNK_pT183_Y185 →	-0.181	-2.124	.001	.001	3	2
UCEC	MEK1 →	+0.358	+2.247	.004	.001	3	2
UCEC	c-Jun_pS73 →	-0.152	-3.797	.004	<.001	3	2
UCEC	EGFR_pY1068 →	-0.225	-1.584	.008	.034	3	1
UCEC	A-Raf_pS299 →	-0.092	-1.584	.024	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FASN by VNN1 expression — UCEC

Explore this box plot interactively →