VNN1

Across TCGA cell cohorts, VNN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,112 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible VNN1-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Antigen processing and presentation of endogenous antigen, and Pattern recognition receptor signaling pathway. Each is linked with VNN1 in more than 11 cancer types. Because this analysis shows association rather than direction, both VNN1-to-partner and partner-to-VNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by VNN1-low versus VNN1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VNN1→partner) and Y-score (partner→VNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cytoplasmic pattern recognition receptor signaling pathway →	+0.074	+0.656	<.001	.009	3	12
BREAST	Antigen processing and presentation of endogenous antigen →	+0.310	+0.633	<.001	<.001	3	10
SOFT_TISSUE	Pattern recognition receptor signaling pathway →	+0.080	+0.877	<.001	.001	3	10
PANCREAS	Response to molecule of bacterial origin →	+0.100	+2.588	<.001	<.001	3	10
PANCREAS	Regulation of adaptive immune response →	+0.069	+2.780	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cellular response to lipopolysaccharide →	+0.084	+1.202	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by VNN1 expression — BREAST

Explore this box plot interactively →