VGLL2

Across TCGA cell cohorts, VGLL2 mutation is significantly associated with the mutation status of many other genes, with 213 significant associations in total. CNS shows the largest number of these associations.

The most reproducible VGLL2-associated genes across cancer lineages are SEMA4C, PGS1, and IRF2BP1. Each is linked with VGLL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VGLL2-to-partner and partner-to-VGLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMA4C grouped by VGLL2-low versus VGLL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VGLL2→partner) and Y-score (partner→VGLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SEMA4C →	+4.187	+5.000	.008	.008	1	1
LUNG_NSCLC_LUAD	PGS1 →	+4.187	+5.000	.008	.008	1	1
CNS	IRF2BP1 →	+6.044	+6.044	.001	.001	1	1
CNS	CDC42BPG →	+4.459	+5.277	.005	.005	1	1
CNS	CLSTN1 →	+4.459	+5.277	.005	.005	1	1
CNS	BANP →	+6.044	+6.044	.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

SEMA4C by VGLL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →