VGLL2

Across TCGA pan-cancer cohorts, VGLL2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of VGLL2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VGLL2 RNA is repressed in tumor relative to normal tissue. In most cancer types VGLL2 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, BRCA, and THCA are the cancer types where VGLL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VGLL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.060	.005	7	view →
BRCA	Female	All	−0.128	.034	2	view →
THCA	Female	II,III,IV	−0.023	.023	2	view →
KIRP	All	All	+0.022	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

VGLL2–HNSC

Open the HNSC breakdown →