VEGFD

Across TCGA patient cohorts, VEGFD mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEGFD-associated genes across cancer lineages are mTOR_pS2448, ASNS, and Caspase-8. Each is linked with VEGFD in more than 1 cancer types. Because this analysis shows association rather than direction, both VEGFD-to-partner and partner-to-VEGFD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by VEGFD-low versus VEGFD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFD→partner) and Y-score (partner→VEGFD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.114	-1.765	.041	.014	3	2
UCEC	ASNS →	+0.461	+1.700	<.001	.042	3	2
UCEC	Caspase-8 →	-0.224	-2.089	.017	.016	3	2
UCEC	FASN →	+0.331	+1.765	.025	.014	3	1
UCEC	ACC1 →	+0.367	+2.598	.007	.005	3	1
UCEC	HER2_pY1248 →	-0.217	-2.169	.030	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by VEGFD expression — UCEC

Explore this box plot interactively →