VEGFD

Across TCGA pan-cancer cohorts, VEGFD RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VEGFD data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher VEGFD RNA is associated with better overall survival. In most high-consensus cancer types, elevated VEGFD expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUAD show a favorable association.

PAAD, KICH, and UVM are the cancer types where VEGFD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Median	All	0.611	0.353	<.001	70	view →
KICH	OS	Median	II,III,IV	0.630	1.000	.006	43	view →
UVM	DFS	Quartile	III,IV	0.265	0.893	.006	33	view →
LGG	DFS	Median	All	0.346	0.525	<.001	32	view →
LUAD	DFS	Quartile	All	0.528	0.338	<.001	31	view →
LUSC	DFS	Quartile	III,IV	0.482	0.758	.007	30	view →
KIRP	DFS	Tertile	All	0.483	0.928	<.001	22	view →
SKCM	DFS	Tertile	II,III,IV	0.662	0.483	.004	20	view →
LIHC	DFS	Tertile	All	0.495	0.671	.007	15	view →
READ	OS	Tertile	III,IV	0.861	0.557	.010	14	view →
SARC	OS	Tertile	All	0.809	0.596	.007	13	view →
BRCA	OS	Quartile	III,IV	0.922	0.776	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VEGFD–PAAD (OS)

Open the PAAD breakdown →