VEGFD

Across TCGA pan-cancer cohorts, VEGFD RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VEGFD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VEGFD RNA is repressed in tumor relative to normal tissue. In most cancer types VEGFD is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and BLCA are the cancer types where VEGFD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VEGFD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−2.323	<.001	12	view →
LUAD	Male	III,IV	−5.130	<.001	11	view →
BLCA	Male	III,IV	−3.821	<.001	11	view →
THCA	Male	III,IV	−0.804	<.001	10	view →
LUSC	Female	II,III,IV	−6.062	<.001	9	view →
LIHC	All	All	+0.776	<.001	9	view →
STAD	All	All	−1.995	<.001	8	view →
READ	Female	All	−3.074	<.001	7	view →
KICH	All	II,III,IV	−1.218	<.001	7	view →
BRCA	Female	II,III,IV	−4.394	<.001	6	view →
UCEC	All	II,III,IV	−2.351	<.001	6	view →
HNSC	All	All	−0.698	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VEGFD–COAD

Open the COAD breakdown →