VEGFC

Across TCGA patient cohorts, VEGFC mutation is significantly associated with the RNA expression of many other genes, with 2,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEGFC-associated genes across cancer lineages are SCO1, TOMM5, and OR10J3. Each is linked with VEGFC in more than 3 cancer types. Because this analysis shows association rather than direction, both VEGFC-to-partner and partner-to-VEGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCO1 grouped by VEGFC-low versus VEGFC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFC→partner) and Y-score (partner→VEGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCO1 →	+0.514	+2.823	<.001	.001	3	4
SKCM	TOMM5 →	+0.303	+1.629	.005	.005	3	4
STAD	OR10J3 →	+0.241	+2.567	<.001	.009	3	3
UCEC	DOC2B →	-0.963	-2.169	.001	.003	3	3
UCEC	CCNB2 →	+0.641	+2.608	.004	.006	3	3
UCEC	POC1A →	+0.557	+3.923	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,724 associations by consensus.

SCO1 by VEGFC expression — UCEC

Explore this box plot interactively →