VEGFC

Across TCGA pan-cancer cohorts, VEGFC RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of VEGFC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VEGFC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VEGFC is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where VEGFC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VEGFC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.343	<.001	11	view →
KIRC	Female	All	+1.322	<.001	11	view →
THCA	All	II,III,IV	−0.549	<.001	9	view →
LIHC	All	II,III,IV	+0.661	<.001	7	view →
UCEC	All	All	−1.784	<.001	6	view →
BRCA	All	II,III,IV	−0.646	<.001	6	view →
CHOL	Female	All	+1.583	.013	2	view →
READ	Male	All	+1.429	.032	2	view →
KIRP	All	IV	+1.375	.048	2	view →
LUSC	Female	All	−1.020	.002	2	view →
LUAD	Female	All	−0.788	<.001	2	view →
STAD	Male	II,III,IV	+0.715	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

VEGFC–HNSC

Open the HNSC breakdown →