VEGFC

Across TCGA pan-cancer cohorts, VEGFC RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated VEGFC data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VEGFC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VEGFC expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

HNSC, LUAD, and ACC are the cancer types where VEGFC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.688	0.812	<.001	100	view →
LUAD	OS	Tertile	All	0.710	0.857	<.001	94	view →
ACC	DFS	Quartile	All	0.126	0.720	<.001	80	view →
MESO	OS	Tertile	All	0.222	0.529	<.001	73	view →
UVM	DFS	Quartile	III,IV	0.250	0.955	<.001	72	view →
KICH	OS	Tertile	III,IV	0.221	0.894	.002	63	view →
KIRP	DFS	Median	III,IV	0.425	0.747	.001	63	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
LUSC	OS	Median	All	0.600	0.716	.009	13	view →
UCEC	DFS	Tertile	IV	0.201	0.507	.034	12	view →
SKCM	OS	Median	II,III,IV	0.907	0.758	.004	11	view →
COAD	DFS	Median	IV	0.347	0.622	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

VEGFC–HNSC (OS)

Open the HNSC breakdown →