VEGFC

Across TCGA patient cohorts, VEGFC mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VEGFC-associated genes across cancer lineages are TFRC, MYH11, and p27_pT157. Each is linked with VEGFC in more than 3 cancer types. Because this analysis shows association rather than direction, both VEGFC-to-partner and partner-to-VEGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by VEGFC-low versus VEGFC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFC→partner) and Y-score (partner→VEGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.661	+2.222	.003	.011	3	4
LUAD	MYH11 →	-1.072	-2.115	.003	.018	3	3
COAD	p27_pT157 →	+0.204	+3.178	.004	.010	3	2
COAD	CD49b →	+0.339	+3.178	.021	.010	3	2
UCEC	eEF2 →	+0.524	+2.906	<.001	.001	3	2
UCEC	FoxM1 →	+0.258	+2.222	.018	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

TFRC by VEGFC expression — UCEC

Explore this box plot interactively →