VEGFC

Across TCGA cell cohorts, VEGFC mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VEGFC-associated genes across cancer lineages are JAK_8517, Sabutoclax, and KRAS (G12C) Inhibitor-12. Each is linked with VEGFC in more than 1 cancer types. Because this analysis shows association rather than direction, both VEGFC-to-partner and partner-to-VEGFC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JAK_8517 grouped by VEGFC-low versus VEGFC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VEGFC→partner) and Y-score (partner→VEGFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JAK_8517 →	+0.841	+2.649	.008	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.520	+2.769	.013	.040	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.517	+2.646	.038	.047	3	1
LARGE_INTESTINE	729189 →	+0.265	+2.649	.038	.046	2	1
LARGE_INTESTINE	XMD15-27 →	+0.267	+2.652	.026	.045	2	1
LARGE_INTESTINE	CP466722 →	+0.511	+2.652	.008	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JAK_8517 by VEGFC expression — LARGE_INTESTINE

Explore this box plot interactively →