VDAC3

Across TCGA cell cohorts, VDAC3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible VDAC3-associated genes across cancer lineages are OR2T1, OR6N2, and MAGEB4. Each is linked with VDAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VDAC3-to-partner and partner-to-VDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T1 grouped by VDAC3-low versus VDAC3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VDAC3→partner) and Y-score (partner→VDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2T1 →	+0.026	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR6N2 →	+0.006	+5.643	.003	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	HSF5 →	+0.006	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2T1 by VDAC3 expression — BLOOD_Lymphoma

Explore this box plot interactively →