VDAC3

Across TCGA pan-cancer cohorts, VDAC3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of VDAC3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where VDAC3 RNA is repressed in tumor relative to normal tissue. In most cancer types VDAC3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where VDAC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VDAC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.496	<.001	11	view →
LIHC	Male	II,III,IV	+0.972	<.001	9	view →
UCEC	All	III,IV	+0.678	.001	8	view →
LUSC	Female	II,III,IV	+0.948	<.001	7	view →
BRCA	All	II,III,IV	+0.424	<.001	6	view →
CHOL	All	All	+1.558	<.001	5	view →
LUAD	Male	All	+0.542	<.001	5	view →
KICH	All	All	−0.510	.002	4	view →
KIRP	All	II,III,IV	+0.441	.005	4	view →
READ	Female	All	−0.729	.002	2	view →
PRAD	All	All	−0.256	.008	2	view →
KIRC	Male	II,III,IV	−0.242	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

VDAC3–THCA

Open the THCA breakdown →