VDAC3

Across TCGA pan-cancer cohorts, VDAC3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated VDAC3 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VDAC3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VDAC3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

LUAD, ACC, and MESO are the cancer types where VDAC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.307	0.585	<.001	102	view →
ACC	OS	Median	II,III,IV	0.745	0.951	<.001	76	view →
MESO	DFS	Quartile	III,IV	0.267	0.516	.005	43	view →
KICH	DFS	Quartile	III,IV	0.079	1.000	.005	38	view →
LIHC	OS	Median	All	0.707	0.850	.002	32	view →
ESCA	DFS	Tertile	II,III,IV	0.415	0.626	.011	31	view →
KIRC	OS	Tertile	All	0.740	0.528	<.001	30	view →
LUSC	OS	Tertile	II,III,IV	0.884	0.611	.013	30	view →
COAD	OS	Quartile	All	0.929	0.820	.004	27	view →
DLBC	DFS	Median	All	0.336	0.858	.005	17	view →
KIRP	DFS	Tertile	All	0.370	0.729	.024	14	view →
STAD	DFS	Quartile	III,IV	0.391	0.700	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

VDAC3–LUAD (DFS)

Open the LUAD breakdown →