Across TCGA pan-cancer cohorts, VDAC1P10 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of VDAC1P10’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where VDAC1P10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VDAC1P10 is over-expressed in tumor.
COAD and LUAD are the cancer types where VDAC1P10 tumor–normal differential expression is most reproducible.