VCX

Across TCGA cell cohorts, VCX mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible VCX-associated genes across cancer lineages are DEFB129, FAM47C, and IQCF6. Each is linked with VCX in more than 1 cancer types. Because this analysis shows association rather than direction, both VCX-to-partner and partner-to-VCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by VCX-low versus VCX-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCX→partner) and Y-score (partner→VCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB129 →	+0.043	+6.022	<.001	.001	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	IQCF6 →	+0.118	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFB129 by VCX expression — SKIN

Explore this box plot interactively →