VCX

Across TCGA pan-cancer cohorts, VCX RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of VCX’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where VCX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types VCX is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUSC, LIHC, and HNSC are the cancer types where VCX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VCX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	+1.044	<.001	7	view →
LIHC	All	All	+0.398	<.001	7	view →
HNSC	All	All	+0.226	.004	6	view →
THCA	All	All	−0.041	.002	5	view →
BRCA	Female	All	+0.178	.004	4	view →
KICH	All	All	+0.085	.001	4	view →
KIRP	All	III,IV	+0.490	.043	3	view →
BLCA	All	All	+0.913	.022	2	view →
LUAD	All	All	+0.277	.006	1	view →
KIRC	All	All	+0.023	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

VCX–LUSC

Open the LUSC breakdown →