VCP

Across TCGA patient cohorts, VCP mutation is significantly associated with the RNA expression of many other genes, with 3,233 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VCP-associated genes across cancer lineages are MIR28, MIR5003, and RNA5SP412. Each is linked with VCP in more than 1 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR28 grouped by VCP-low versus VCP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR28 →	+0.319	+5.655	.001	.004	3	2
LIHC	MIR5003 →	+0.356	+4.647	<.001	.007	3	2
UCEC	RNA5SP412 →	+0.423	+1.829	<.001	.001	3	2
CESC	FBLIM1P2 →	+0.074	+4.760	<.001	.003	3	2
COAD	RNU6-836P →	+0.333	+4.225	<.001	.007	3	2
COAD	RNU6-878P →	+0.275	+4.278	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,233 associations by consensus.

MIR28 by VCP expression — HNSC

Explore this box plot interactively →