VCP

Across TCGA pan-cancer cohorts, VCP RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated VCP data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VCP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VCP expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

LUAD, KIRC, and SCLC are the cancer types where VCP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.716	0.862	<.001	93	view →
KIRC	DFS	Median	All	0.715	0.526	<.001	78	view →
SCLC	OS	Median	All	0.708	0.411	<.001	70	view →
UVM	DFS	Median	All	0.441	0.720	.002	70	view →
ACC	DFS	Tertile	All	0.250	0.698	.002	49	view →
MESO	DFS	Median	IV	0.170	0.531	<.001	42	view →
LIHC	OS	Tertile	All	0.689	0.860	<.001	40	view →
UCEC	DFS	Tertile	III,IV	0.777	0.502	.009	38	view →
OV	OS	Tertile	IV	0.791	0.491	.024	12	view →
SKCM	DFS	Median	II,III,IV	0.626	0.791	.004	11	view →
KICH	DFS	Quartile	II,III,IV	0.618	1.000	.016	10	view →
LGG	OS	Quartile	All	0.731	0.852	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

VCP–LUAD (DFS)

Open the LUAD breakdown →