VCP

Across TCGA cell cohorts, VCP mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VCP-associated genes across cancer lineages are ACER1, PRKACG, and SH3GL2. Each is linked with VCP in more than 1 cancer types. Because this analysis shows association rather than direction, both VCP-to-partner and partner-to-VCP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by VCP-low versus VCP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCP→partner) and Y-score (partner→VCP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.078	+3.408	.001	<.001	3	2
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.417	+3.252	<.001	.009	3	1
LARGE_INTESTINE	OR2C1 →	+0.122	+2.841	<.001	.006	3	1
BLOOD_Lymphoma	FSHB →	+0.016	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ACER1 by VCP expression — LARGE_INTESTINE

Explore this box plot interactively →