VCL

Across TCGA cell cohorts, VCL mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VCL-associated genes across cancer lineages are OR4F5, ASB17, and C12orf40. Each is linked with VCL in more than 1 cancer types. Because this analysis shows association rather than direction, both VCL-to-partner and partner-to-VCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by VCL-low versus VCL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VCL→partner) and Y-score (partner→VCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F5 →	+0.012	+2.667	.002	<.001	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	VSIG4 →	+0.010	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR1Q1 →	+0.071	+4.082	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

OR4F5 by VCL expression — LARGE_INTESTINE

Explore this box plot interactively →