VCL

Across TCGA pan-cancer cohorts, VCL RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated VCL data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher VCL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VCL expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

MESO, BLCA, and KICH are the cancer types where VCL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.391	0.688	<.001	111	view →
BLCA	DFS	Tertile	All	0.176	0.575	<.001	78	view →
KICH	OS	Tertile	II,III,IV	0.529	1.000	.001	55	view →
KIRC	OS	Tertile	All	0.744	0.561	.001	50	view →
PAAD	OS	Quartile	All	0.246	0.620	<.001	31	view →
UVM	DFS	Tertile	III,IV	0.323	0.722	.017	28	view →
LUAD	OS	Quartile	All	0.278	0.433	.008	26	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
LAML	DFS	Quartile	All	0.269	0.640	.005	24	view →
LGG	OS	Tertile	All	0.444	0.669	.001	21	view →
UCEC	DFS	Median	IV	0.654	0.296	.020	18	view →
CESC	DFS	Median	III,IV	0.618	0.828	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

VCL–MESO (OS)

Open the MESO breakdown →