VAX1

Across TCGA patient cohorts, VAX1 mutation is significantly associated with the RNA expression of many other genes, with 2,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VAX1-associated genes across cancer lineages are UHRF1, SMIM10L2A, and AURKB. Each is linked with VAX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VAX1-to-partner and partner-to-VAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by VAX1-low versus VAX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX1→partner) and Y-score (partner→VAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.767	+2.403	<.001	<.001	3	2
UCEC	SMIM10L2A →	-0.530	-3.437	.008	.005	3	2
UCEC	AURKB →	+0.559	+2.431	.008	.001	3	2
UCEC	C9orf50 →	-0.527	-2.392	<.001	<.001	3	2
COAD	POLR2A →	+0.857	+3.210	<.001	.009	3	2
UCEC	GINS3 →	+0.559	+2.413	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,315 associations by consensus.

UHRF1 by VAX1 expression — UCEC

Explore this box plot interactively →