VAX1

Across TCGA pan-cancer cohorts, VAX1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated VAX1 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher VAX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated VAX1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

UVM, LUAD, and ACC are the cancer types where VAX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.398	0.799	<.001	134	view →
LUAD	DFS	Median	All	0.579	0.714	<.001	92	view →
ACC	DFS	Median	All	0.474	0.805	<.001	79	view →
COAD	DFS	Median	IV	0.211	0.650	<.001	62	view →
THYM	DFS	Tertile	III,IV	0.171	0.816	.004	60	view →
KIRP	OS	Quartile	All	0.436	0.737	<.001	36	view →
STAD	OS	Quartile	II,III,IV	0.458	0.637	.005	31	view →
HNSC	OS	Quartile	All	0.709	0.794	.010	31	view →
UCS	DFS	Quartile	II,III,IV	0.525	0.184	.014	30	view →
LAML	DFS	Tertile	All	0.258	0.520	.029	24	view →
BRCA	DFS	Median	III,IV	0.818	0.909	.020	20	view →
LIHC	OS	Tertile	All	0.521	0.737	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

VAX1–UVM (OS)

Open the UVM breakdown →