VAX1

Across TCGA cell cohorts, VAX1 mutation is significantly associated with the mutation status of many other genes, with 1,174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VAX1-associated genes across cancer lineages are MAP9, NLGN3, and ZNF69. Each is linked with VAX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both VAX1-to-partner and partner-to-VAX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP9 grouped by VAX1-low versus VAX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VAX1→partner) and Y-score (partner→VAX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAP9 →	+5.339	+4.772	.004	.004	1	3
LARGE_INTESTINE	NLGN3 →	+4.672	+5.329	<.001	<.001	1	3
LUNG_NSCLC_LUAD	ZNF69 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	RCSD1 →	+5.339	+4.772	.004	.004	1	3
BLOOD_Leukemia	CNNM1 →	+4.000	+5.050	.008	.008	1	3
LUNG_NSCLC_LUAD	ZC3H11A →	+5.339	+4.772	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,174 associations by consensus.

MAP9 by VAX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →