VANGL2

Across TCGA cell cohorts, VANGL2 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VANGL2-associated genes across cancer lineages are OR3A1, FAM90A26, and TRIM64B. Each is linked with VANGL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VANGL2-to-partner and partner-to-VANGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A1 grouped by VANGL2-low versus VANGL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VANGL2→partner) and Y-score (partner→VANGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	2
LARGE_INTESTINE	FAM90A26 →	+0.005	+2.514	<.001	.007	3	2
CNS	TRIM64B →	+0.442	+4.643	<.001	.003	3	1
CNS	KRTAP5-6 →	+0.079	+4.832	<.001	.002	3	1
CNS	OR5H8 →	+0.022	+4.754	<.001	.005	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

OR3A1 by VANGL2 expression — BLOOD_Leukemia

Explore this box plot interactively →