UVRAG-DT

Across TCGA pan-cancer cohorts, UVRAG-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UVRAG-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where UVRAG-DT RNA is repressed in tumor relative to normal tissue. In most cancer types UVRAG-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where UVRAG-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UVRAG-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.565	<.001	8	view →
BLCA	All	All	+0.387	.003	7	view →
THCA	Male	All	−0.268	<.001	6	view →
STAD	All	II,III,IV	+0.265	.002	6	view →
COAD	All	II,III,IV	+0.176	<.001	6	view →
BRCA	Female	All	−0.375	<.001	4	view →
LIHC	Male	All	+0.243	<.001	4	view →
HNSC	All	II,III,IV	−0.212	.013	3	view →
READ	All	All	+0.250	.005	2	view →
KIRP	All	II,III,IV	+0.221	.026	2	view →
LUAD	Male	All	+0.248	.035	1	view →
LUSC	All	All	+0.108	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UVRAG-DT–KICH

Open the KICH breakdown →