UTS2R

Across TCGA pan-cancer cohorts, UTS2R RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated UTS2R data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UTS2R RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated UTS2R expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where UTS2R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.641	0.445	<.001	79	view →
SKCM	OS	Median	All	0.427	0.266	<.001	71	view →
BRCA	OS	Tertile	All	0.984	0.938	<.001	64	view →
UVM	OS	Tertile	All	0.377	0.715	.003	59	view →
ACC	DFS	Tertile	All	0.406	0.661	.004	44	view →
KIRC	OS	Tertile	All	0.537	0.719	.002	37	view →
BLCA	OS	Median	IV	0.736	0.379	.004	34	view →
LUAD	OS	Quartile	All	0.611	0.295	.010	34	view →
DLBC	DFS	Median	All	0.308	0.811	.004	33	view →
STAD	DFS	Quartile	All	0.547	0.739	.008	29	view →
OV	DFS	Tertile	All	0.438	0.345	.011	22	view →
SCLC	DFS	Quartile	All	0.835	0.462	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

UTS2R–HNSC (DFS)

Open the HNSC breakdown →