UTRN

Across TCGA patient cohorts, UTRN mutation is significantly associated with the RNA expression of many other genes, with 8,731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTRN-associated genes across cancer lineages are MASTL, ECHS1, and LARP1B. Each is linked with UTRN in more than 5 cancer types. Because this analysis shows association rather than direction, both UTRN-to-partner and partner-to-UTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MASTL grouped by UTRN-low versus UTRN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTRN→partner) and Y-score (partner→UTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MASTL →	+0.512	+1.945	.001	.002	3	5
SKCM	ECHS1 →	+0.316	+3.858	<.001	<.001	3	5
UCEC	LARP1B →	+0.483	+1.468	<.001	<.001	3	5
SKCM	GDI2 →	+0.360	+2.019	.008	.001	3	5
COAD	PSMC1 →	+0.362	+2.917	<.001	<.001	3	5
UCEC	SRP54 →	+0.364	+1.457	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,731 associations by consensus.

MASTL by UTRN expression — SKCM

Explore this box plot interactively →