UTRN

Across TCGA cell cohorts, UTRN mutation is significantly associated with the RNA expression of many other genes, with 1,433 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UTRN-associated genes across cancer lineages are NEK4, C18orf25, and ATP5IF1. Each is linked with UTRN in more than 4 cancer types. Because this analysis shows association rather than direction, both UTRN-to-partner and partner-to-UTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEK4 grouped by UTRN-low versus UTRN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTRN→partner) and Y-score (partner→UTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEK4 →	+0.478	+2.000	.004	.009	3	4
LARGE_INTESTINE	C18orf25 →	+0.518	+1.545	.005	.004	2	5
LARGE_INTESTINE	ATP5IF1 →	+0.519	+3.321	<.001	.002	3	3
LARGE_INTESTINE	MMS22L →	+0.688	+2.000	<.001	.009	3	3
BLOOD_Leukemia	CNNM2 →	+0.568	+3.176	<.001	.008	3	3
LARGE_INTESTINE	RAPGEF6 →	+0.435	+1.631	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,433 associations by consensus.

NEK4 by UTRN expression — LARGE_INTESTINE

Explore this box plot interactively →