UTF1

Across TCGA cell cohorts, UTF1 RNA expression is significantly associated with the mutation status of many other genes, with 261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UTF1-associated genes across cancer lineages are FMO4, UTRN, and PLXNB1. Each is linked with UTF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UTF1-to-partner and partner-to-UTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO4 grouped by UTF1-low versus UTF1-high in SKIN.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTF1→partner) and Y-score (partner→UTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FMO4 →	+4.022	+0.010	.006	<.001	3	3
LUNG_NSCLC_LUSC	UTRN →	+4.643	+0.136	.008	<.001	3	2
LUNG_NSCLC_LUSC	PLXNB1 →	+4.643	+0.136	.008	<.001	3	2
LUNG_NSCLC_LUSC	DSEL →	+4.643	+0.136	.008	<.001	3	2
BREAST	TSHZ2 →	+3.672	+0.048	.006	<.001	3	2
LARGE_INTESTINE	CCNJ →	+5.632	+0.031	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 261 associations by consensus.

FMO4 by UTF1 expression — SKIN

Explore this box plot interactively →