UTF1

Across TCGA pan-cancer cohorts, UTF1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UTF1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where UTF1 RNA is repressed in tumor relative to normal tissue. In most cancer types UTF1 is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.

UCEC, KIRC, and LUSC are the cancer types where UTF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UTF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.498	.001	6	view →
KIRC	Male	II,III,IV	+0.057	<.001	6	view →
LUSC	Female	All	−0.114	.003	3	view →
ESCA	All	II,III,IV	+0.195	.023	2	view →
LUAD	All	All	−0.099	.005	2	view →
LIHC	All	All	+0.027	.029	2	view →
READ	All	II,III,IV	+0.357	.030	1	view →
THCA	Male	All	+0.082	.012	1	view →
KIRP	All	All	+0.063	.038	1	view →
KICH	All	All	−0.052	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UTF1–UCEC

Open the UCEC breakdown →