USP9Y

Across TCGA patient cohorts, USP9Y protein abundance is significantly associated with the RNA expression of many other genes, with 2,723 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible USP9Y-associated genes across cancer lineages are TMSB4Y, PSMA6P1, and MTCYBP2. Each is linked with USP9Y in more than 4 cancer types. Because this analysis shows association rather than direction, both USP9Y-to-partner and partner-to-USP9Y results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP9Y versus TMSB4Y in GBM, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP9Y→partner) and Y-score (partner→USP9Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMSB4Y →	+1.792	+1.105	<.001	<.001	3	5
GBM	PSMA6P1 →	+2.923	+1.154	<.001	<.001	3	4
GBM	MTCYBP2 →	+2.306	+1.100	<.001	<.001	3	4
GBM	AGKP1 →	+3.113	+1.067	<.001	<.001	3	4
GBM	CDY4P →	+2.138	+1.114	<.001	<.001	3	4
CCRCC	LINC00278 →	+2.848	+0.962	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,723 associations by consensus.

USP9Y vs TMSB4Y — GBM

Explore this scatter interactively →