USP9Y

Across TCGA pan-cancer cohorts, USP9Y RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of USP9Y’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where USP9Y RNA is repressed in tumor relative to normal tissue. In most cancer types USP9Y is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where USP9Y tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP9Y RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−2.049	<.001	6	view →
KICH	Female	All	−0.009	<.001	6	view →
HNSC	Male	II,III,IV	−0.989	.001	5	view →
KIRC	Male	All	−0.786	<.001	4	view →
PRAD	All	All	+0.434	.007	2	view →
CHOL	Male	All	+1.351	.040	1	view →
STAD	Male	All	−0.788	.026	1	view →
THCA	Male	III,IV	−0.678	.038	1	view →
LUSC	Male	All	−0.595	.007	1	view →
COAD	Female	All	+0.011	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

USP9Y–KIRP

Open the KIRP breakdown →