USP9Y

Across TCGA pan-cancer cohorts, USP9Y RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated USP9Y data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP9Y RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated USP9Y expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, THCA, and UVM are the cancer types where USP9Y RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.424	0.246	<.001	119	view →
THCA	DFS	Median	All	0.746	0.875	<.001	80	view →
UVM	DFS	Median	All	0.941	0.545	.001	51	view →
LUAD	OS	Median	II,III,IV	0.323	0.620	.004	26	view →
MESO	DFS	Quartile	All	0.080	0.648	.025	18	view →
UCEC	DFS	Tertile	All	0.763	0.857	.006	18	view →
KIRC	OS	Quartile	II,III,IV	0.615	0.448	.029	17	view →
SKCM	DFS	Tertile	All	0.639	0.800	.021	12	view →
LGG	DFS	Median	All	0.742	0.887	.001	8	view →
SCLC	OS	Tertile	All	0.512	0.702	.028	7	view →
ACC	DFS	Median	All	0.860	0.618	.013	6	view →
COAD	DFS	Quartile	III,IV	0.712	0.240	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

USP9Y–HNSC (DFS)

Open the HNSC breakdown →