USP9Y

Across TCGA cell cohorts, USP9Y mutation is significantly associated with the mutation status of many other genes, with 975 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP9Y-associated genes across cancer lineages are CYP2C19, LEMD3, and SUGP2. Each is linked with USP9Y in more than 2 cancer types. Because this analysis shows association rather than direction, both USP9Y-to-partner and partner-to-USP9Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP2C19 grouped by USP9Y-low versus USP9Y-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP9Y→partner) and Y-score (partner→USP9Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CYP2C19 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	LEMD3 →	+3.362	+4.754	.002	.002	1	3
LARGE_INTESTINE	SUGP2 →	+3.087	+4.392	.005	.005	1	2
BLOOD_Lymphoma	FAH →	+4.584	+4.584	.007	.007	1	2
BLOOD_Lymphoma	INTS9 →	+4.584	+4.584	.007	.007	1	2
BLOOD_Lymphoma	AKAP10 →	+4.584	+4.584	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

CYP2C19 by USP9Y expression — BLOOD_Lymphoma

Explore this box plot interactively →