Across TCGA patient cohorts, USP7 protein abundance is significantly associated with the RNA expression of many other genes, with 14,372 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USP7-associated genes across cancer lineages are GLYR1, PDPK1, and POLR3E. Each is linked with USP7 in more than 6 cancer types. Because this analysis shows association rather than direction, both USP7-to-partner and partner-to-USP7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP7→partner) and Y-score (partner→USP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GLYR1 →	+0.566	+0.301	<.001	<.001	3	7
COAD	PDPK1 →	+0.649	+0.334	<.001	<.001	3	7
GBM	POLR3E →	+0.499	+0.224	<.001	<.001	3	7
HNSC	CYTH4 →	-0.670	-0.110	<.001	.003	3	7
LSCC	TFAP4 →	+0.718	+0.236	<.001	<.001	3	7
LSCC	GSPT1 →	+0.415	+0.201	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,372 associations by consensus.

Exploration

USP7 survival (RNA) · tumor vs normal (RNA) · all USP7 data types