Across TCGA pan-cancer cohorts, USP7 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated USP7 data layer compared with 8 for mutation status and 4 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher USP7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated USP7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.
KIRC, LUAD, and THYM are the cancer types where USP7 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.