Across TCGA patient cohorts, USP7 mutation is significantly associated with the RNA expression of many other genes, with 3,662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP7-associated genes across cancer lineages are ENO2, MSANTD3, and ALDOA. Each is linked with USP7 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP7-to-partner and partner-to-USP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP7→partner) and Y-score (partner→USP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ENO2 →	+1.061	+3.700	<.001	.001	3	4
UCEC	MSANTD3 →	+0.608	+2.868	<.001	<.001	3	4
UCEC	ALDOA →	+0.424	+2.169	.001	<.001	3	4
UCEC	LACTB →	+0.368	+2.839	.001	.001	3	4
UCEC	EXOSC9 →	+0.372	+2.024	.002	.005	3	4
COAD	WDR62 →	+0.566	+2.834	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,662 associations by consensus.

Exploration

USP7 survival (RNA) · tumor vs normal (RNA) · all USP7 data types