USP7

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, USP7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP7-associated genes across cancer lineages are PKC-a_pS657, EGFR_pY1068, and eIF4E. Each is linked with USP7 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP7-to-partner and partner-to-USP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP7→partner) and Y-score (partner→USP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPKC-a_pS657 →-0.271-1.575.048.03433
UCECEGFR_pY1068 →-0.266-1.925.003.00532
UCECeIF4E →+0.171+2.321.024.00132
UCECINPP4B →-0.299-2.222.010.00932
UCECJNK_pT183_Y185 →-0.145-1.571.016.01932
UCECMEK1 →+0.363+2.321.005.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration