Across TCGA cell cohorts, USP7 mutation is significantly associated with the RNA expression of many other genes, with 512 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP7-associated genes across cancer lineages are CWF19L1, FREM3, and RAD51C. Each is linked with USP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP7-to-partner and partner-to-USP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP7→partner) and Y-score (partner→USP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CWF19L1 →	+0.643	+3.176	<.001	.008	3	2
SKIN	FREM3 →	+0.068	+3.196	<.001	.007	3	2
LARGE_INTESTINE	RAD51C →	+0.923	+3.299	.002	.004	3	2
LARGE_INTESTINE	SIKE1 →	+0.667	+3.234	.002	.004	3	2
SOFT_TISSUE	OR51A4 →	+0.006	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR4M2 →	+0.081	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 512 associations by consensus.

Exploration

USP7 survival (RNA) · tumor vs normal (RNA) · all USP7 data types