Across TCGA cell cohorts, USP7 mutation is significantly associated with the mutation status of many other genes, with 7,665 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP7-associated genes across cancer lineages are TENM3, TBC1D9B, and TENM1. Each is linked with USP7 in more than 5 cancer types. Because this analysis shows association rather than direction, both USP7-to-partner and partner-to-USP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP7→partner) and Y-score (partner→USP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TENM3 →	+1.793	+4.145	<.001	<.001	1	6
STOMACH	TBC1D9B →	+4.807	+4.807	.008	.008	1	5
LARGE_INTESTINE	TENM1 →	+1.833	+3.261	<.001	<.001	1	5
BLOOD_Leukemia	TRPC4 →	+3.080	+2.675	.004	.004	1	5
BLOOD_Lymphoma	NCOR2 →	+2.706	+4.609	<.001	<.001	1	4
BLOOD_Lymphoma	SRC →	+4.969	+4.014	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,665 associations by consensus.

Exploration

USP7 survival (RNA) · tumor vs normal (RNA) · all USP7 data types