USP6

Across TCGA cell cohorts, USP6 mutation is significantly associated with the RNA expression of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP6-associated genes across cancer lineages are OR1L3, DIRAS2, and PRND. Each is linked with USP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP6-to-partner and partner-to-USP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by USP6-low versus USP6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP6→partner) and Y-score (partner→USP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR1L3 →	+0.016	+4.169	<.001	<.001	3	2
BLOOD_Leukemia	DIRAS2 →	+0.055	+2.814	<.001	.008	3	2
BLOOD_Leukemia	PRND →	+0.006	+3.289	<.001	.002	3	2
BLOOD_Leukemia	GPRIN2 →	+0.029	+3.004	<.001	.007	3	2
BLOOD_Leukemia	ELOA3P →	+0.186	+3.477	<.001	.009	3	2
LARGE_INTESTINE	FAM149A →	+1.680	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

OR1L3 by USP6 expression — BREAST

Explore this box plot interactively →