USP6

Across TCGA pan-cancer cohorts, USP6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of USP6’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where USP6 RNA is repressed in tumor relative to normal tissue. In most cancer types USP6 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and CHOL are the cancer types where USP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.517	<.001	6	view →
KICH	Female	II,III,IV	−0.150	<.001	5	view →
CHOL	All	All	+0.210	.001	3	view →
LIHC	All	All	+0.034	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

USP6–BRCA

Open the BRCA breakdown →