USP5

Across TCGA patient cohorts, USP5 protein abundance is significantly associated with the RNA expression of many other genes, with 7,334 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USP5-associated genes across cancer lineages are CD27-AS1, PLEKHA5, and ADIPOR2. Each is linked with USP5 in more than 6 cancer types. Because this analysis shows association rather than direction, both USP5-to-partner and partner-to-USP5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP5 versus CD27-AS1 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP5→partner) and Y-score (partner→USP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD27-AS1 →	+0.898	+0.230	<.001	.001	3	7
CCRCC	PLEKHA5 →	+0.892	+0.183	<.001	<.001	3	7
UCEC	ADIPOR2 →	+0.649	+0.137	.002	.003	3	7
LSCC	STRAP →	+0.549	+0.239	<.001	<.001	3	7
LSCC	RPL13P5 →	+0.514	+0.288	<.001	<.001	3	7
LSCC	ING4 →	+0.637	+0.302	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,334 associations by consensus.

USP5 vs CD27-AS1 — HNSC

Explore this scatter interactively →