USP44

Across TCGA cell cohorts, USP44 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,432 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP44-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, Protein-DNA complex organization, and Positive regulation of viral genome replication. Each is linked with USP44 in more than 9 cancer types. Because this analysis shows association rather than direction, both USP44-to-partner and partner-to-USP44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by USP44-low versus USP44-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP44→partner) and Y-score (partner→USP44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of ubiquitin protein ligase activity →	-0.191	-1.617	.001	.005	3	10
BLOOD_Lymphoma	Protein-DNA complex organization →	+0.040	+1.288	<.001	<.001	3	9
LUNG_SCLC	Positive regulation of viral genome replication →	+0.124	+1.493	<.001	<.001	3	9
BLOOD_Myeloma	Positive regulation of mRNA metabolic process →	+0.043	+0.021	.006	<.001	2	9
URINARY_TRACT	Negative regulation of ubiquitin-protein transferase activity →	-0.146	-1.224	<.001	.001	3	8
BONE	Positive regulation of DNA repair →	+0.073	+1.718	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,432 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by USP44 expression — LIVER

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