USP44

Across TCGA cell cohorts, USP44 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP44-associated genes across cancer lineages are RSPH6A, NABP2, and ASCL3. Each is linked with USP44 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP44-to-partner and partner-to-USP44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by USP44-low versus USP44-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP44→partner) and Y-score (partner→USP44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.107	+3.866	.001	.002	3	1
LARGE_INTESTINE	NABP2 →	+0.479	+3.215	.007	.009	3	1
LARGE_INTESTINE	ASCL3 →	+0.150	+2.989	<.001	.003	3	1
LARGE_INTESTINE	ELOA3DP →	+0.020	+3.009	<.001	.001	3	1
LARGE_INTESTINE	TECRL →	+0.009	+2.977	.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.164	+2.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RSPH6A by USP44 expression — LARGE_INTESTINE

Explore this box plot interactively →