USP36

Across TCGA patient cohorts, USP36 mutation is significantly associated with the RNA expression of many other genes, with 4,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP36-associated genes across cancer lineages are PRC1, CDADC1, and OIP5. Each is linked with USP36 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP36-to-partner and partner-to-USP36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by USP36-low versus USP36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP36→partner) and Y-score (partner→USP36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRC1 →	+0.645	+1.825	<.001	<.001	3	3
UCEC	CDADC1 →	+0.272	+2.202	<.001	<.001	3	3
UCEC	OIP5 →	+0.691	+1.847	<.001	<.001	3	3
STAD	SMC3 →	+0.717	+3.347	<.001	.004	3	3
UCEC	CNOT6 →	+0.284	+1.384	.005	<.001	3	3
SKCM	RRP9 →	+0.456	+3.526	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,858 associations by consensus.

PRC1 by USP36 expression — UCEC

Explore this box plot interactively →